Drug for Advanced Skin Cancer Wins FDA Approval

Drug for Advanced Skin Cancer Wins FDA Approval


Drug for Advanced Skin Cancer Wins FDA Approval

Posted: 31 Jan 2012 01:00 PM PST

face in mirror, woman, skin, looking at skin
CREDIT: Yuri Arcurs | Dreamstime

The Food and Drug Administration has for the first time approved a drug to treat advanced cases of the most common skin cancer, basal cell carcinoma, the agency announced yesterday (Jan. 30).

The drug, a capsule called Erivedge (generically known as vismodegib), treats basal cell carcinoma that has metastasized (spread through the body), or that cannot be treated with surgery.

In a clinical study in 96 people, 30 percent of those with locally advanced basal cell carcinoma (which had spread to surrounding tissue), and 43 percent of those with metastatic cancer (which had spread to distant sites in the body) saw their tumors shrink or heal while taking the drug, according to a statement from the FDA. Patients took one pill by mouth each day.  

Doctors treat non-metastatic cases with surgery, radiation or topical treatments, and have an extremely high success rate. But no other treatments exist for inoperable cases, such as people with tumors that have extended into the brain, or people who would become disfigured from surgery.

"This is exciting," said Dr. Désirée Ratner, director of dermatologic surgery at Columbia University Medical Center in New York. "I treat high-risk cases that are doable with surgery, but now there is a nonsurgical medical option for large, very advanced cases."

Ratner said she once had a patient whose tumor covered her entire upper back, and spread into her neck. That patient was not eligible for surgery, she said, but would perhaps have been a candidate for this drug, she said.   

Stopping the spread

Basal cell carcinoma originates in the top layer of the skin, spreads slowly and accounts for 80 percent of all skin cancer cases in the U.S. Each year about 2 million people in the U.S. receive a diagnosis of basal cell carcinoma, making it the country's most common skin cancer. However, less than 1 percent of diagnoses are metastatic. 

Factors that raise a person's risk include having fair, freckly skin, and being chronically exposed to the sun.

The FDA statement noted that Erivedge caused a range of side effects, including muscle spasms, hair loss, weight loss, nausea, fatigue, decreased appetite, vomiting and loss of taste. 

Pregnant women should not take Erivedge, as it could kill or harm a fetus, the agency said. 

How it works

Basal cell carcinoma is linked to mutations in genes that are part of a signaling pathway called the hedgehog pathway. Erivedge works by inhibiting the hedgehog pathway. 

In addition to helping patients with skin cancer, Erivedge might also treat people with other cancers, such as medulloblastoma, a malignant brain tumor that occurs in children; pancreatic cancer; and a type of lung cancer. The drug is currently in trials for other cancers.

Erivedge is produced by the company Genentech. 

Pass it on: The drug Erivedge has been approved for the treatment of metastatic basal cell carcinoma.

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FPMT a Documentary

This Documentary is a Work in Progress that explores the history and future of FPMT and the Mahayana Tradition. For more information: www.fpmt.org

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Spiritual Self Help – 3 Essential Steps to Achieving Spiritual Enlightenment

Posted: 31 Jan 2012 12:00 PM PST

Article by Nelson Berry

Spiritual self help is designed to help anyone who want to embark on a journey towards spiritual awareness, growth, and development. One common problem among people these days is the lack of contentment and a detachment from their inner selves. This, in truth, is the common aim of any religion in the world. Inside each of us lies a spiritual being seeking to be set free. Unfortunately, most people have mistaken religion as a tradition to follow or as a routine or activity. Only a very small percentage of every religion achieves true spiritual enlightenment.

Do you think that a mundane life void of passion is what you're made for? Do you think that religion is all about outward activities and inward nothingness? Don't settle for anything less than what you're meant to experience in this life.

Spiritual self help can help you reach your true destiny. It can help you maintain composure and peace in the face of life's challenges, and can give you access to your deepest emotions.

1. Get in touch with the inner you. This may sound like a cliché, which is why it is often taken for granted. But the truth is that there is a spiritual being residing inside you. In fact, you are not a physical being seeking for spirituality; you are a spiritual being only residing in a physical body.

The problem is, today's materialistic world has made us into physical beings that are disconnected from the spiritual beings that we really are. This spiritual being recedes into the background and becomes a faint haunting inside us that we are made for something more.

So what you have to do is find this spiritual being inside you. Once you get in touch with that part of you, you will be overwhelmed with its innate passion, love, and peace – everything you need to live the life you've always dreamed.

2. Rest your mind. To achieve spiritual awareness, you need to give your mind some time to breath. Don't let it get cluttered with day to day concerns. Don't juggle ! multiple trains of thought at once. If you busy your mind up, it becomes more and more detached to its true power. If you let your mind rest regularly, you will be able to see an unlimited space which can be filled with peace and contentment, from which we can draw strength in life's biggest challenges.

3. Remove all doubts. There is no more powerful force that can drive you further from spiritual awakening than doubt. If you doubt the existence of that powerful spiritual being inside you, then it won't manifest itself in any way. The problem is, the conscious mind is naturally full of doubts; it's just the way it is wired due to the way it perceives this rather tricky society.

Thankfully, there is a way to remove all negative thoughts and beliefs from your mind so you can free it to believe in the power inside you. This is the use of subliminal messages to uproot all the doubts embedded even in the deepest recesses of your mind.

Here are some examples of positive subliminal messages that can awaken the spiritual power inside you:

I am a spiritual being. I am in touch with the powerful spirit that dwells in me.The spirit of peace and contenment lives inside me.

About the Author

Nelson Berry is the Pioneer of Subliminal Messages Videos and Subliminal MP3s Audio Subliminal Messages online. Valued at 0, click for 4 Free Subliminal messages!

Pam Reynold's Near Death Experience

This case comes the closest to hard evidence that consciousness survives physical death. During her brain operation, blood was drained from the brain and the heart stopped. She was incapable of hallucinating, yet she was out of the body and her observations come close to proving it. Debunkers have worked extra hard to try to disprove this case. But cardiologist Michael Sabom who studied this case and others says that Pam Reynolds was really out of the body and having a spiritual experience. Consciousness can survive physical death.

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Marijuana Mouth Spray: Will Cancer Pain Reliever Be Abused?

Posted: 31 Jan 2012 12:00 PM PST

sativex, medical marijuana, marijuana mouth spray, pain relief
CREDIT: GW Pharmaceuticals

The medical marijuana drug Sativex, which could be approved in the United States in the coming years as a treatment for pain relief, has little potential for abuse, experts say.

The British pharmaceutical company GW Pharma is currently testing the drug, which is delivered as a mouth spray and called Sativex, in clinical trials. The company plans to seek U.S. Food and Drug Administration approval for the drug as a treatment for cancer pain when the trials are completed, likely sometime in 2014, a spokesperson for GW Pharma told MyHealthNewsDaily.

The active ingredients in Sativex, known as cannabinoids, are derived from the cannabis plant. It is the first marijuana-based drug to be made by extracting the compounds from the plant, rather than synthesizing them. Two other drugs, Marinol and Cesamet, based on synthetic cannabinoids, were approved by the FDA in the 1980s.

Because the drug contains THC, the ingredient primarily responsible for marijuana's "high," it's possible people would use the drug for recreational rather than medical purposes.

"There is no doubt in my mind that there will be people that abuse it," said Dr. Jeffrey Bernstein, director of the Florida Poison Information Center at the University of Miami Miller School of Medicine.

However, because the drug is delivered through ingestion, rather than smoking, it would take much longer to have an effect — at least an hour, compared with the minutes it takes to get high after smoking marijuana, said Margaret Haney, a professor of clinical neurobiology at Columbia University. This means drug users seeking a high would be less likely to abuse it. "Smoking is a really effective way to get a chemical into the brain," Haney said. The mouth spray "is a far safer administration,"she said.

And Marinol and Cesamet, which are also administered orally, have a low rate of abuse. "We don't see a lot of problems from [those]," Bernstein said.

Not the same high

GW Pharma intends to market Sativex in the United States for treatment of cancer pain. The drug is already approved in United Kingdom, Spain, Canada and New Zealand to treat muscle spasms due to multiple sclerosis, according to the company website.

Patients can adjust the dose of Sativex to prevent it from entering the blood too rapidly, allowing them to experience symptom relief without the marijuana high, according to GW Pharma.

In addition, while marijuana is a hodgepodge of about 64 different substances, Sativex is composed mainly of two ingredients: THC and another cannabinoid called CBD. The latter component is thought to ameliorate some of the side effects of THC, including the high that marijuana users feel, said Dr. Armando Villarreal, an assistant professor of neurosurgery and pain management at the University of Rochester Medical Center in New York.

And for habitual marijuana users, the cultural and ritualistic practices that go along with smoking pot, such as passing a joint, may be an important part of the experience, Bernstein said. These rituals cannot be replicated with the spray. "A lot of people that smoke marijuana would rather smoke it," he said.

Unlikely overdose

Unlike drugs such as painkillers, which come with a risk of death if people take too much, patients who   "overdose" on the marijuana spray would be at little risk for acute health problems, Haney said.

"What could happen is the person could get very uncomfortably intoxicated," Haney said. But in terms of other serious health effects, "there's none that I know of," Haney said.

"Marijuana, in the scheme of things, is a relativity safe drug," Bernstein said. "Even as a smokeable drug of abuse, it's relatively safe…compared to cocaine or heroin."

However, Villarreal noted that for people with psychiatric disorders, smoking marijuana has been shown to make the patients' mental problems worse. It's possible Sativex may also cause this problem in some patients, he said.

Could it help patients?

So far, the studies that have been conducted do not provide enough evidence to say Sativex is effective in improving pain symptoms, Villarreal said.

Sativex has mainly been tested as a drug to treat pain caused by damaged nerves. If the drug is approved by the FDA, Villarreal speculated, its use could be restricted to certain pain patients. Those with cancer pain that is not caused by damaged nerves may not be candidates for the drug, Villarreal said.

About 1 in 11 people who try pot end up addicted to it, Haney said. It would be interesting to study whether Sativex could help people in dependent marijuana users quite the drug, she said.

Pass it on: Because it takes longer for people to get high from an oral form of marijuana, there is little potential for abuse of a marijuana-based mouth spray.

Follow MyHealthNewsDaily staff writer Rachael Rettner on Twitter @RachaelRettner. Find us on Facebook.

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The Height of Happiness - 52-min documentary

See full film here: vodsite.journeyman.tv April 2008 Long thought of as a secluded paradise hidden deep in the Himalayas, and renowned for its pursuit of happiness over economic prosperity, Bhutan now struggles to accommodate the invasion of tourists, new media and western materialism in the twenty first century. As monks play with condoms, clowns offer advice on AIDS and farmers feed cannabis to pigs, we hear the thoughts of Government officials, Stress Reduction monks, tourists and ordinary Bhutanese themselves, as they face up to the challenge to the underlying spiritualism of this mystical country and its rapidly changing identity in an internet shrunk world.

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Your Mind Creates Everything

Posted: 31 Jan 2012 11:00 AM PST

Article by John Duffey

Your mind is the mechanism that brings into your life everything you first created in your mind. It is your ability to use your mind to imagine and visualise what you want that determines how quickly and accurately you bring into existence your desires and goals.

Everything you see around you, absolutely everything, was first created in some ones mind. Even the Universe was first conceived and created in the mind of the Creator God. All the houses, cars, parks and gardens and electrical goods, were all conceived and created in the mind of some one.

It is how you plan, imagine, visualise and create in your mind that determines how accurately you bring into existence what you desire to come about.

Much of what comes into your life, whether good or bad, arrived because you activated the primal law of creation, which is known as the Law of Attraction. Immediately you begin to plan and desire something, the Law of Attraction begins to bring you what you want. It attracts to you all the new related thoughts that support your plan, it brings the people you need at the right time and the inspiring ideas that come out of the 'Blue' help you achieve what you have planned. By some spiritual mechanism your plan or desire begins to materialise. Your mind is the spirit link to activating the Law of Attraction and your mind is also your spirit link with the Creator.

Like Attracts Like... this is the Law of Attraction in action. Like attracts like is the key to understanding how bad things happen just as easily as good things happen!

If you use your mind in anger, hatred or jealousy this emotion is picked up instantly by the Law of Attraction. And just like the pulling power of the Law of Gravity, what you conceived in your mind come right at you. If you keep thinking thoughts of anger, lack or impossibility - that is what you get.

Now you will begin to understand why anger and racial hatred is fuelling the Middle East crisis. While ever those people keep focussing on hatred a! nd anger that is what they are creating more of.

It behoves everyone to stop focussing on racial hatreds and fear and anger in all its forms, and deliberately change ones thoughts to imagining and visualising being happy, friendly and successful. Just this one step will begin removing the fear and hatreds around one and world conditions will improve.

It is a matter of using ones mind to deliberately change ones thoughts and visualise more pleasant life experiences. And then that is what you get. Powerful imaging and visualising of what you want to see materialise in your daily life is the answer to all successful outcomes in your life.

To create a success business is simply a matter of strongly imaging and visualising the preferred outcomes you are looking for. Visualise vividly, like seeing a movie on the screen of your mind, the huge numbers of customers coming into your business and buying your products. Visualise how big you want the business to grow. Visualise how big you want your income to be. Write this whole plan down, then every day bring the images and visualising of your plan to mind. The idea is to keep this plan to the forefront of your subconscious mind until it accepts the idea and acts on it by activating the Law of Attraction.

If you don't think you can visualise, do you know what a red apple looks like? Your mind just visualised an apple instantly and you saw it on the screen of your mind. Practice imagining what an apple looks like and then turn it around in your mind and look for the core. What does a pink poodle look like? You can easily create in your mind what you want.

I have found the Law of Attraction works brilliantly with creating an Internet Business. The linking principles involved with the worldwide web seem to mirror how the mind links with the Law of Attraction and brings into being what you desire quite quickly.

About the Author

John Duffey writes on a variety of subjects. To learn more about this topic John recommends you visit his site and look for his Blog link on http://www.checkjohn.com




Chronic Illnesses Need More Attention, Report Says

Posted: 31 Jan 2012 11:00 AM PST

cancer-patients-100910-02
CREDIT: Dreamstime

More action from federal, state and local governments is needed to address the increasing burden of chronic illness in the United States, according to a new report.

The report, compiled by an Institute of Medicine committee, makes recommendations on how to improve the lives of people with long-term and sometimes disabling conditions, such as dementia and chronic pain, a problem the committee says will only get worse as the population ages.

The recommendations include a call to gather more information about people with multiple chronic conditions, such as those who have both Type 2 diabetes and heart disease, to better understand how to manage these patients. Today, more than one in four Americans live with multiple chronic conditions, the report says.

"The epidemic of chronic illness is steadily moving toward crisis proportions, yet maintaining or enhancing quality of life for individuals living with chronic illnesses has not been given the attention it deserves by health care funders, health systems, policymakers, and public health programs and agencies," the authors of the report wrote.

Nearly 48 million Americans report having a disability due to chronic illness, and 75 percent of health care costs are spent on medical care for people with these conditions.

The Centers for Disease Control and Prevention (CDC) should select a variety of diseases that merit special public health action, the report said. The illnesses selected should be ones for which prevention programs would be most effective.

When gathering data on chronic diseases, the CDC should examine which diseases occur together, the order in which the conditions tend to appear and the impact the co-occurring diseases have.

The CDC should also study people over time to look at "risk factors that could predict how a given illness will progress over time and how having a single chronic disease increases the odds of suffering from additional ailments," the report says.

The U.S. Department of Health and Human Services should support states in developing plans to manage chronic disease among its residence, including community-based efforts to help chronic disease suffers, such as cognitive training programs and better access to mobility aids.

The report was complied upon request of the CDC and the Arthritis Foundation.

Pass it on: Many people live with chronic illnesses, but these diseases have not received the attention they deserve from public health action plans.

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108 Japanese Temples

www.taleofgenji.org A tour of 108 ancient Meditation temples in Kyoto, Nara and other areas of Western Japan. Details and photos of the temples can be found at http

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I'm In 3 Minds About This Article

Posted: 31 Jan 2012 10:27 AM PST

Article by Jonathan Martin Clark

You probably know that you have a conscious mind, don't you? The part of you that answered - that was it! It likes experience, knowledge, mental power, analysis and rationality. It also likes respect, admiration, significance and success. It's focussed on specifics, likes order and sequence, and it usually kicks in at about age five. Unfortunately, it's also an expert in denying and avoiding pain. But did you know that you also have an unconscious..........mind as well? And you may also realise that you have a Higher Self too. This is the second major teaching of HGE - that you are of three minds.

Our ancestors used to teach this, as the Father, Son and Holy Ghost. Ever wonder why it's in that order? This trinity is present in every tradition on the planet. The Pope's cross has 3 horizontal bars, the Cardinal's only two, and the Priests only has one. Hmmm. Or the Lovers Card in the Major Arcana of the Tarot Cards. There's a man (conscious mind) looking at a woman (unconscious mind), but she's looking above him at an angel (higher self) which he can't see. Think of it as the child, the parent and the grandparent. You'll never be alone again when you realise that there's three of you in there.

You're more than just a Conscious Mind. It thinks, "I am". But you also have an unconscious Mind with feelings, "I feel". It runs your body, beats your heart, stores your memories, controls your emotions. It's sometimes called the "body/mind". It's like a timid animal with basic desires and a mental age of about five years old. It adores food, clothes, security, sex, fun, the five senses and safety. It has no words.

You always know you're really at the unconscious level when you have no words for the feelings you're experiencing. Any time you criticise yourself, you're criticising your unconscious mind. People treat their pets better than their own unconscious. Society likes to keep you out of here - men are taught to be unemotional, therapists will help you manage your anger (rather than! clear i t up completely) and prescription drugs suppress your true feelings. They're still there, you just can't feel them. So the next time a red light appears on your car dashboard, just paint black paint over it. It's still a problem, but at least you can't see it.

Many believe you have a third self, the Higher Conscious Mind also, with still more, higher functions, such as wisdom, order, justice, ecology, peace, truth, perfection and evolution. This is the spiritual part of you, your guardian angel, and it looks down at you like a totally trustworthy parent gazing lovingly on a perfect child (you). It creates anything that you ask for, (whether dwell on good things or bad) including health and energy, as well as more tangible goals.

Now there's a connection linking the Conscious Mind to the Unconscious Mind, and another linking the Unconscious Mind to your Higher Self. But there's no direct connection between the Conscious Mind and the Higher Self. The only way to get communication with your Higher Self, is to first learn how to connect with your unconscious mind. Hence the use of Hypnosis, or trance in HGE, where you go inside...

The Physical body is the vehicle for the whole package. That's why visualisation with feeling works better than affirmation - the former impacts the unconscious mind, and thus the Emotional and Physical bodies. Affirmations are Mental body, conscious statements. Does that make sense?

Daddy Bray, a Hawaiian teacher or Kahuna said that the lesson of life is for the Unconscious Mind to become conscious, and for the Conscious Mind to become a Higher Self. Your conscious mind's job is to teach the unconscious mind and grow it up, so it becomes a conscious mind. Strive to make the hidden contents of your unconscious, conscious. He also said that the lesson of Mastery was for the Higher Self to come down into the consciousness, and for the conscious mind to merge with the unconscious.

Become a Higher self and integrate that back into your physical life.! Bring y our spiritual nature all the way down into the physical body. Then you can truly and profoundly affect other people in your daily life.

Oh and by the way, your unconscious mind looks up at you like an awestruck child - you are a God in it's eyes. Your Higher Self looks down at you as perfect, in every way, right now. It's only your conscious mind that needs convincing...

About the Author

Jonathan Clark provides advice and inspiration in what to do next for talented individuals who want greater hope and certainty in their personal and professional lives. For a free info pack visit http://www.thelatentpowerofyou.com

Mind Boosters: to Improve Mood, Memory, and Mindfulness

Let's face it: the quality of our brain's biochemistry profoundly Influences the thinking powers and emotional tone of our mind. Modern research has shown a link that you can influence for the better. Learn about amino acids and neurotransmitters, the pathway out of depression, and energy enhancers that reawaken your cognitive edge. Dr. Ron takes you on a fantastic voyage through brain chemistry, setting sail for optimal mental health and a better quality of life. ---------- Presenter: Ron Hunninghake, MD Download: riordanclinic.org ---------- TheRiordan Clinic is a not-for-profit 501(c)3 organization focused on orthomolecular medicine, health education and health research. To learn more about the Riordan Clinic or to make a donation, please visit www.riordanclinic.org

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Drug for Advanced Skin Cancer Wins FDA Approval

Posted: 31 Jan 2012 10:08 AM PST


face in mirror, woman, skin, looking at skin
CREDIT: Yuri Arcurs | Dreamstime

The Food and Drug Administration has for the first time approved a drug to treat advanced cases of the most common skin cancer, basal cell carcinoma, the agency announced yesterday (Jan. 30).

The drug, a capsule called Erivedge (generically known as vismodegib), treats basal cell carcinoma that has metastasized (spread through the body), or that cannot be treated with surgery.

In a clinical study in 96 people, 30 percent of those with locally advanced basal cell carcinoma (which had spread to surrounding tissue), and 43 percent of those with metastatic cancer (which had spread to distant sites in the body) saw their tumors shrink or heal while taking the drug, according to a statement from the FDA. Patients took one pill by mouth each day.

Doctors treat non-metastatic cases with surgery, radiation or topical treatments, and have an extremely high success rate. But no other treatments exist for inoperable cases, such as people with tumors that have extended into the brain, or people who would become disfigured from surgery.

"This is exciting," said Dr. Désirée Ratner, director of dermatologic surgery at Columbia University Medical Center in New York. "I treat high-risk cases that are doable with surgery, but now there is a nonsurgical medical option for large, very advanced cases."

Ratner said she once had a patient whose tumor covered her entire upper back, and spread into her neck. That patient was not eligible for surgery, she said, but would perhaps have been a candidate for this drug, she said.

Stopping the spread

Basal cell carcinoma originates in the top layer of the skin, spreads slowly and accounts for 80 percent of all skin cancer cases in the U.S. Each year about 2 million people in the U.S. receive a diagnosis of basal cell carcinoma, making it the country's most common skin cancer. However, less than 1 percent of diagnoses are metastatic.

Factors that raise a person's risk include having fair, freckly skin, and being chronically exposed to the sun.

The FDA statement noted that Erivedge caused a range of side effects, including muscle spasms, hair loss, weight loss, nausea, fatigue, decreased appetite, vomiting and loss of taste.

Pregnant women should not take Erivedge, as it could kill or harm a fetus, the agency said.

How it works

Basal cell carcinoma is linked to mutations in genes that are part of a signaling pathway called the hedgehog pathway. Erivedge works by inhibiting the hedgehog pathway.

In addition to helping patients with skin cancer, Erivedge might also treat people with other cancers, such as medulloblastoma, a malignant brain tumor that occurs in children; pancreatic cancer; and a type of lung cancer. The drug is currently in trials for other cancers.

Erivedge is produced by the company Genentech.

Pass it on: The drug Erivedge has been approved for the treatment of metastatic basal cell carcinoma.

Follow MyHealthNewsDaily on Twitter @MyHealth_MHND. Find us on Facebook.

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Marijuana Mouth Spray: Will Cancer Pain Reliever Be Abused?

Posted: 31 Jan 2012 10:08 AM PST


sativex, medical marijuana, marijuana mouth spray, pain relief
CREDIT: GW Pharmaceuticals

The medical marijuana drug Sativex, which could be approved in the United States in the coming years as a treatment for pain relief, has little potential for abuse, experts say.

The British pharmaceutical company GW Pharma is currently testing the drug, which is delivered as a mouth spray and called Sativex, in clinical trials. The company plans to seek U.S. Food and Drug Administration approval for the drug as a treatment for cancer pain when the trials are completed, likely sometime in 2014, a spokesperson for GW Pharma told MyHealthNewsDaily.

The active ingredients in Sativex, known as cannabinoids, are derived from the cannabis plant. It is the first marijuana-based drug to be made by extracting the compounds from the plant, rather than synthesizing them. Two other drugs, Marinol and Cesamet, based on synthetic cannabinoids, were approved by the FDA in the 1980s.

Because the drug contains THC, the ingredient primarily responsible for marijuana's "high," it's possible people would use the drug for recreational rather than medical purposes.

"There is no doubt in my mind that there will be people that abuse it," said Dr. Jeffrey Bernstein, director of the Florida Poison Information Center at the University of Miami Miller School of Medicine.

However, because the drug is delivered through ingestion, rather than smoking, it would take much longer to have an effect — at least an hour, compared with the minutes it takes to get high after smoking marijuana, said Margaret Haney, a professor of clinical neurobiology at Columbia University. This means drug users seeking a high would be less likely to abuse it. "Smoking is a really effective way to get a chemical into the brain," Haney said. The mouth spray "is a far safer administration,"she said.

And Marinol and Cesamet, which are also administered orally, have a low rate of abuse. "We don't see a lot of problems from [those]," Bernstein said.

Not the same high

GW Pharma intends to market Sativex in the United States for treatment of cancer pain. The drug is already approved in United Kingdom, Spain, Canada and New Zealand to treat muscle spasms due to multiple sclerosis, according to the company website.

Patients can adjust the dose of Sativex to prevent it from entering the blood too rapidly, allowing them to experience symptom relief without the marijuana high, according to GW Pharma.

In addition, while marijuana is a hodgepodge of about 64 different substances, Sativex is composed mainly of two ingredients: THC and another cannabinoid called CBD. The latter component is thought to ameliorate some of the side effects of THC, including the high that marijuana users feel, said Dr. Armando Villarreal, an assistant professor of neurosurgery and pain management at the University of Rochester Medical Center in New York.

And for habitual marijuana users, the cultural and ritualistic practices that go along with smoking pot, such as passing a joint, may be an important part of the experience, Bernstein said. These rituals cannot be replicated with the spray. "A lot of people that smoke marijuana would rather smoke it," he said.

Unlikely overdose

Unlike drugs such as painkillers, which come with a risk of death if people take too much, patients who "overdose" on the marijuana spray would be at little risk for acute health problems, Haney said.

"What could happen is the person could get very uncomfortably intoxicated," Haney said. But in terms of other serious health effects, "there's none that I know of," Haney said.

"Marijuana, in the scheme of things, is a relativity safe drug," Bernstein said. "Even as a smokeable drug of abuse, it's relatively safe…compared to cocaine or heroin."

However, Villarreal noted that for people with psychiatric disorders, smoking marijuana has been shown to make the patients' mental problems worse. It's possible Sativex may also cause this problem in some patients, he said.

Could it help patients?

So far, the studies that have been conducted do not provide enough evidence to say Sativex is effective in improving pain symptoms, Villarreal said.

Sativex has mainly been tested as a drug to treat pain caused by damaged nerves. If the drug is approved by the FDA, Villarreal speculated, its use could be restricted to certain pain patients. Those with cancer pain that is not caused by damaged nerves may not be candidates for the drug, Villarreal said.

About 1 in 11 people who try pot end up addicted to it, Haney said. It would be interesting to study whether Sativex could help people in dependent marijuana users quite the drug, she said.

Pass it on: Because it takes longer for people to get high from an oral form of marijuana, there is little potential for abuse of a marijuana-based mouth spray.

Follow MyHealthNewsDaily staff writer Rachael Rettner on Twitter @RachaelRettner. Find us on Facebook.

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Freedom: The Path To Happiness

Ajahn Brahm: For those abused and wronged is happiness actually possible? Attachment to painful emotions, such as grief, anger, bitterness, the notion of a wounded self with a distinct identity: all these can become a perpetual prison...

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Approaching Buddhahood

Posted: 31 Jan 2012 10:09 AM PST

For the sake of discussion, let's assume that some great Lama or Spiritual Consciousness is able to empower you. All of a sudden the Mind or Buddha-nature that was hidden by your desires comes out in almost full force. The bliss is overwhelming. But then three days later it all goes away. You're depressed. You want to know what happened. Well, the answer is easy. You still have too much desire for the material world. Such desire is like a dark cloud that eventually, in a matter of days, hides the great sun of the Buddha-nature. This desire, I should mention, is just the habit of chasing after Mind's phenomenalizations strongly believing that they are other than illusory.

The lesson I wish to impart here is that even with bodhicittotpada (the emergence of the mind that is bodhi) or the same, Bodhi Mind, there are still a lot of bad habits we have to jettison. However, the more we set them aside, the more outshining will be Mind and its power. When pure Mind is such that it is more than our desires for anything of the material world, including our clinging to the psychophysical body, we are approaching Buddhahood.

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Ven. Rahula - Yoga: Good Meditation Posture

Yoga demonstration of what to pay attention to to develop good meditation posture. For more detail, download Venerable's book 'The Body/Mind Connection' for free at www.archive.org Also download Ven. Rahula's autobiography 'One Night's Shelter' for free at www.archive.org

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Early Morning Meditation Inspiration - 1/31/2012

Posted: 31 Jan 2012 10:09 AM PST


"Hatred does not cease by hatred, but only by love; this is the eternal rule."

~The Buddha


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TS: Living Realization: An Interview with Scott Kiloby

Posted: 31 Jan 2012 10:10 AM PST

Podcast: Play in new window | Download (Duration: 1:04:10 — 73.4MB)

Living RealizationAre you suffering and seeking relief? Is your life dominated by what Eckhart Tolle calls the Pain Body? Are you unable to find fulfillment no matter where you go or what you do? Do you seek inner peace and love and compassion for others? In this episode, Greg interviews Scott Kiloby, who shares his special approach to realizing presence, awareness, and inner joy.

In this episode of the Living With Tolle Podcast, we continue our search for teachings that enhance our understanding of Eckhart Tolle and invite us to experience the Power of Now. Greg interviews Scott Kiloby, who explains that freedom is available and actually contained in your very presence. Inspired by Eckhart Tolle and other non-duality teachers, Scott shares his special approach to realizing presence, awareness, and inner joy.

Just as Eckhart invites us to practice witnessing the pain body and the circumstances of the present moment, Scott also explains that "many teachings invite people to turn away from the content of their lives. My new approach invites us to go through the specific content of our lives, using it as the doorway to freedom. This new approach is more personal and allows for very specific inquiry and dialoguing."

Scott also offers these basic reminders for practicing Living Realization:

  • Recognize awareness throughout the day.
  • Let all appearances be as they are.
  • See that all appearances are inseparable.

We invite you to listen and put into practice the wisdom and guidance that Scott offers during this conversation. We also encourage you to share this conversation with your friends and experience "living realization" as you explore the simple, yet effective, guidance and practices that Scott provides!

About Scott Kiloby

Scott KilobyScott is the author of "Love's Quiet Revolution: The End of the Spiritual Search" and "Reflections of the One Life: Daily Pointers to Enlightenment ." He is also the creator of an addiction/recovery method called "The Natural Rest Method: A Revolutionary, Simple Way to Overcome Any Addiction," which is scheduled for release in 2011.

Scott Kiloby began writing the Living Realization material in 2008. Through the years, Scott has revised the text, responding to issues that have popped up in his own spiritual journey as well as in one-on-one and group meetings with others.

He is a noted author and international speaker who gives talks or meetings in which those attending experience nondual presence. In these meetings, every position and belief gets challenged, including every belief about the self, others, the world and also all of our ideas about spirituality. This leaves those attending completely open to allow the present moment to unfold in a new way, free of identification with thought.

The point of the meetings is to allow each person attending to go home and discover for themselves the freedom Scott's message is pointing to. The live meetings are spontaneous, open, and unpredictable.

Scott's other website is www.kiloby.com.

It contains many writings, videos and audio clips, as well as interviews with a wide diversity of other
teachers, authors, scientists, and psychologists.

Enjoy & Share!
Leo & Greg

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Universe may not be eternal, but existence is

Posted: 31 Jan 2012 10:10 AM PST

Believers in God who follow modern science will be heartened by a recent article in New Scientist, "Why physicists can't avoid a creation event."

While many of us may be OK with the idea of the big bang simply starting everything, physicists, including Hawking, tend to shy away from cosmic genesis. "A point of creation would be a place where science broke down. One would have to appeal to religion and the hand of God," Hawking told the meeting, at the University of Cambridge, in a pre-recorded speech.

For a while it looked like it might be possible to dodge this problem, by relying on models such as an eternally inflating or cyclic universe, both of which seemed to continue infinitely in the past as well as the future. Perhaps surprisingly, these were also both compatible with the big bang, the idea that the universe most likely burst forth from an extremely dense, hot state about 13.7 billion years ago.

However, as cosmologist Alexander Vilenkin of Tufts University in Boston explained last week, that hope has been gradually fading and may now be dead. He showed that all these theories still demand a beginning.

To me, though, I don't see why a beginning to the universe implies anything about the "hand of God" being the cause of creation.

If we didn't know that our galaxy is part of the vastly larger universe, it'd be easy to think that the formation of our solar system can be traced back to the mysterious formation of the Milky Way Galaxy, before which time and space supposedly couldn't exist.

Several decades into the twentieth century, there wasn't any firm evidence of other galaxies. Now, we know there are at least a hundred billion galaxies. So religious believers and unbelievers alike should be extremely cautious about assuming that what we now know about reality is anywhere close to the ultimate truth.

The big bang banged. Our universe came into being. How? From where? Why? When? Nobody knows. It's a mystery.

According to the article, some theories of modern physicists -- eternal inflation, cyclic universe, static cosmic egg -- seem to be on the ropes, inconsistent with mathematical models. What's surprising about that? What I find surprising is that we humans have been able to make as much progress as we have toward understanding the origin of the universe, and how it has evolved during its post-big bang history of 14 billion years.

Sure, us Homo sapiens are the most intelligent great apes.

We've come a long way over the past few million years, far surpassing what other primates are able to achieve, knowledge-wise. Yet it's important to keep in mind that in comparison with cosmic time, monkeys and humans shared a common ancestor just a blink of an eye ago.

I doubt we'll ever be able to comprehend what the cosmos as a whole is like, which probably includes much more than just the universe in which we find ourselves. I doubt even more that we'll ever be able to know, really know, how the origin of everything in existence came to be.

When I say "we," I mean humans. Almost certainly, our species will die out one day. Perhaps more advanced earthly species will evolve capabilities of consciousness which will enable them to grok stuff we're utterly incapable of understanding.

Let's suppose some conscious being, somewhere, some time, somehow, grasps (or is) the ultimate truth of the cosmos. This being knows. It groks. It's so attuned to the Absolute Truth of Existence there's not even a Planck length of distance between the being and that truth. This being does its best to communicate what it knows to us humans. And I wonder...

Would we have any chance of understanding? Of knowing what that being knows? Of fitting our repository of limited human truths into whatever lies at the heart of the entire cosmos, our unimaginably vast universe plus all that lies beyond what we know now?

I doubt that we could. I doubt that our great ape consciousness, no matter how evolved it is compared to our primate cousins, would be able to take in the Absolute Truth of Existence and make much sense of it.

Reminds me of Douglas Adam's Total Perspective Vortex.

The Total Perspective Vortex derives its picture of the whole Universe on the principle of extrapolated matter analyses.

To explain — since every piece of matter in the Universe is in some way affected by every other piece of matter in the Universe, it is in theory possible to extrapolate the whole of creation — every sun, every planet, their orbits, their composition and their economic and social history from, say, one small piece of fairy cake.

The man who invented the Total Perspective Vortex did so basically in order to annoy his wife.
Trin Tragula — for that was his name — was a dreamer, a thinker, a speculative philosopher or, as his wife would have it, an idiot.

And she would nag him incessantly about the utterly inordinate amount of time he spent staring out into space, or mulling over the mechanics of safety pins, or doing spectrographic analyses of pieces of fairy cake.

"Have some sense of proportion!" she would say, sometimes as often as thirty-eight times in a single day.

And so he built the Total Perspective Vortex — just to show her.

And into one end he plugged the whole of reality as extrapolated from a piece of fairy cake, and into the other end he plugged his wife: so that when he turned it on she saw in one instant the whole infinity of creation and herself in relation to it.

To Trin Tragula's horror, the shock completely annihilated her brain; but to his satisfaction he realized that he had proved conclusively that if life is going to exist in a Universe of this size, then the one thing it cannot afford to have is a sense of proportion.

Exactly.

I'd like to know what the cosmos is all about. But not at the cost of having my brain annihilated. I don't want to end up in a mental hospital muttering to anyone who'll listen, "The universe is... is... is..." Heck, that's akin to what I was up to back in the sixties. Been there, done that.

So I'm pretty much content to accept that I'll never know how or why our universe was created in the big bang. Nor will scientists, at least not in the foreseeable future. I can picture the big bang banging, yet what it banged from or what it is banging into... that's beyond my mind's pay grade.

Back when I wrote "Existence exists. Amazing!" I was more open to the possibility that somehow human consciousness could be the missing piece that completes the jigsaw puzzle of reality. Well, it's still a possibility.

Now I enjoy contemplating the beauty of boundless existence without feeling that I'll ever understand it. Something always has been, even if the universe hasn't. Wow. Beautiful.

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長崎1 Nagasaki Part 1

Nagasaki is located at Kyushu. Glover Garden グラバー園 is a park in Nagasaki, Japan built for Thomas Blake Glover, a Scottish entrepreneur who contributed to the modernization of Japan. In it stands the Glover Residence, the oldest Western style house surviving in Japan and Nagasaki's foremost tourist attraction. Confucius Shrine 孔子廟 Kōshi-byō in Nagasaki, Japan is said to be the world's only Confucian shrine built outside China by Chinese hands. Sofukuji 崇福寺 was constructed in 1629 for Nagasaki's Chinese residents according to contemporary Chinese architecture. Consequently, the temple looks and feels more Chinese than other temples in Japan. Tōmeizan Kōfuku-ji 東明山興福寺 is an Ōbaku Zen Buddhist temple established in 1624 in Nagasaki, Japan. It is an important cultural asset designated by the government.

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Do you know how to be happy?

Posted: 31 Jan 2012 10:13 AM PST

The pursuit of happiness. Everybody is doing it, but many do not know where to find it. It remains elusive. We may not even agree about the definition. Is it having success and recognition on your job? Or is it having expensive things such as expensive cars and homes?

Studies have shown that the happiest people are not those that have the most "things" and the most money. People who are recognized on their jobs are certainly happier than those who are not but it is not the final answer.

Many people do not understand that they are responsible for their own happiness. Someone else cannot make you happy. Things and people around you cannot cause your happiness or misery. It all depends on how you decide to respond to them, it is your decision whether or not you choose to be happy.

Happiness does not come from outside but comes from inside each one of us. The good news is that we all have the capacity.

Some tips for happiness are:

1. Adopt an attitude of gratitude: Make a daily list of the blessings you have. Happiness does not come in iamenting about what you don't have but in appreciating what you do have.

2. Help someone eise: Helping someone can get the focus away from you and how you are feeling and shift it onto others who need your help, it can also limit the time you have for feeling sorry for yourself.

3. Get your priorities in order: Spend more time developing and nurturing your relationships. Connect with the important peopie in your life and make new friends.

4. Do not compare yourself with others: Someone will always have more than you have and someone will have less than you have. Some will have talents, opportunities and strengths that you do not have and you will have talents, opportunities and strengths that they do not have.

5. Take care of yourself: Exercise, sleep well, and eat healthy foods.

6. Use prayer or meditation: This will help to clear your mind and give you renewed energy, serenity and focus.

7. Recognize what you can control: Focus on what you can control and change and less on getting others to change.

8. Listen more and talk less: You will learn more and grow more when listening than when talking.

David Gannon, Ph.D., Psychological and Family Consultants, Canton, Ohio.

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How to Prevent iPad Shoulder Pain

Posted: 31 Jan 2012 10:11 AM PST


CREDIT: Tablet photo via Shutterstock

If your shoulder hurts after using your tablet, you may be able to ease the discomfort by changing how you hold the device, a new study shows.

Compared with users of desktop computers, tablet users are more likey to sit in a flexed posture — which can lead to neck and shoulder discomfort — because of the low angle at which people tend to hold their head and neck while viewing a tablet's screen, the researchers said.

Placing the tablet on a higher surface, such as on a table rather than on your lap, will improve your posture, according to the study, which was conducted by researchers at the Harvard School of Public Health, the Microsoft Corporation and Brigham and Women's Hospital in Boston.

In the study, 15 experienced tablet users completed a series of tasks using two media tablets — the Apple iPad2 and the Motorola Xoom. Each tablet had a case that could be adjusted to tilt it, or prop it up.

The participants used the tablets in four typical user positions: they placed a tablet in their laps while also holding it in their hands, they held it on their laps and in a case, they had it on a table and in a case, and they used it resting atop a table and in a case set at a high angle, fit for watching movies.

In each position, the participants completed simple computer tasks, such as browsing the Internet and playing games. Their head and neck postures, gaze angles and distance from the tablet were measured using a motion-analysis system.

The findings showed that the users' posture was best when the devices were set at their steepest angle. This suggests that users should place tablets on a surface that is higher than their lap, such as on a table, to avoid low gaze angles. They should also use a case that provides steeper viewing angles, the researchers advised.

However, the study showed that steeper angles may be detrimental for tasks requiring your hands, such as typing a long email. The researchers said that further studies examining the effects of tablet placement on users' posture are needed.

"Our results will be useful for updating ergonomic computing standards and guidelines for tablet computers," study researcher Jack T. Dennerlein of the Harvard School of Public Health, said in a statement.

The study was published in the January issue of Work: A Journal of Prevention, Assessment, and Rehabilitation.

Pass it on: Placing your tablet computer on a table rather than on your lap and using a tablet cover with a steep tilt angle may ease shoulder discomfort.

Follow Remy Melina on Twitter @remymelina, and follow MyHealthNewsDaily @MyHealth_MHND. Like us on Facebook.

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